For integrating partner statements with multi-currency support in Odoo 16, you can use the free module "Partner Ledger Multi-Currency Report." This module allows you to generate partner statements with detailed information in multiple currencies, accommodating the exchange rates and currency differences. First you have to enable the multi-currency in settings.
Thank You....

Its missing the total amount in currency

Hi, I am having the same problem Moe has. I need to see the totals divided by currency. The partner ledger shows the original currency of the transaction, then is showed in the accounting currency and then the total showed only in the accounting currency. 

Is it any way to see the totals in the ledger per original currency?

Managing of multi currency is standard in Odoo.  You can register any bill / invoice in any currency that is activated.  The value in currency will show on the partner ledger, as well as the value in company currency.  What are you missing?